李瑶

发布时间：2021-07-12浏览次数：6134

教师基本信息

姓名：李瑶（Yao Li）

职称：教授（Professor）

职务：遗传系主任（Head of the Department of Genetics）

电子邮箱：yaoli@fudan.edu.cn

办公地点：复旦大学江湾校区生命科学学院C517

办公电话：021-31246559

研究方向

肿瘤功能基因组研究; 基因表达调控研究; 非编码RNA的作用及机制研究

Functional genomics of tumours; regulation of gene expression; role and mechanism of non-coding RNAs.

授课情况

细胞生物学（Cell Biology）

招生专业

遗传学（Genetics）

个人简介

1982-1989年就读复旦大学生命科学学院，1986年获复旦大学生物学学士学位，1989年获复旦大学生物学硕士学位，1989-1990年在四川四达生物工程公司从事生化制药的产品开发工作。1990-1993年就读复旦大学生命科学学院，1993年获复旦大学生物学博士学位，1993年至今复旦大学生命学院任教。1995年在香港科技大学生物系作博士后，1997-1999年在美国美国纽约州立大学布法罗分校生物系作博士后，1996年任副教授，2003年任教授。共发表SCI论文125篇，其中通讯作者和第一作者共77篇，获得授权专利20项，主编书籍5本，参编7本。

主持过国家重大专项、863项目、国自然基金面上项目等10余项国家级科研项目，和多项上海市项目。

Yao Li studied at the School of Life Sciences, Fudan University from 1982 to 1989, received her B.S. degree in Biology from Fudan University in 1986, and her M.S. degree in Biology from Fudan University in 1989, and was engaged in the product development of biochemical pharmaceuticals at Sichuan Sida Bioengineering Co. from 1989 to 1990.She received her PhD degree in Biology from Fudan University in 1993, and has been teaching in the School of Life Sciences of Fudan University since 1993, and was a postdoctoral fellow at the Department of Biology, The Hong Kong University of Science and Technology (HKUST) in 1995, and a postdoctoral fellow at the Department of Biology, State University of New York at Buffalo (SUNY-Buffalo) in 1997-1999. She has published 125 SCI papers, including 77 corresponding and first authors, 20 patents, 5 edited books and 7 co-edited books.

She has presided over more than 10 national research projects such as National Major Projects, 863 projects, and top-level projects of the National Natural Fund of China, as well as many projects in Shanghai.

获奖情况

曾获上海市科技进步一等奖、二等奖、教育部科学技术进步二等奖、江苏省科技进步奖二等奖等。2010年获全国劳模称号。

She was awarded the first and second prizes of Shanghai Scientific and Technological Progress, the second prize of Scientific and Technological Progress of the Ministry of Education, the second prize of Jiangsu Scientific and Technological Progress Award, etc. In 2010, she was awarded the title of National Model Worker.

代表性论文：

  1. Kong Z, Lu Y, Yang Y, Chang K, Lin Y, Huang Y, Wang C, Zhang L, Xu W, Zhao S, Li Y. m6A-mediated biogenesis of circDDIT4 inhibits prostate cancer progression by sequestrating ELAVL1/HuR . Mol Cancer Res. 2023 Dec 1;21(12):1342-1355.  

  2. Liang Y, Lu Y, Chen Q, Cheng Y, Ma Y, Huang Y, Qiu M, Li Y. Identification of Long Noncoding RNAs That Exert Transcriptional Regulation by Forming RNA-DNA Triplexes in Prostate Cancer. Int J Mol Sci. 2023 Jan 19;24(3):2035.  

  3. K Feng K, Shi Q, Jiao D, Chen Y, Yang W, Su K, Wang Y, Huang Y, Zhang P, Li Y, Wang C. SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF. Cell Biosci. 2022 Dec 30;12(1):211.

  4. Huang W, Chen Q, Lu Y, Kong Z, Wan X, Huang Y, Qiu M, Li Y. Androgen-Responsive Oncogenic lncRNA RP11-1023L17.1 Enhances c-Myc Protein Stability in Prostate Cancer. Int J Mol Sci. 2022 Oct 13;23(20):12219.

  5. Lu Y, Lin Y, Zhang X, Yan J, Kong Z, Zhang L, Wang C, Huang Y, Zhao S, Li Y. LncRNA-AP006284.1 promotes prostate cancer cell growth and motility by forming RNA-DNA triplexes and recruiting GNL3/SFPQ complex to facilitate RASSF7 transcription. Genes Dis, . 2022 Apr 26;10(2):317-320.

  6. Qin R, Zhao C, Wang CJ, Xu W, Zhao JY, Lin Y, Yuan YY, Lin PC, Li Y, Zhao S, Huang Y.Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation. J Immunother Cancer. 2021 Jul;9(7):e002840.

  7. Jiang M, Cheng Y, Wang D, Lu Y, Gu S, Wang C, Huang Y, Li Y. Transcriptional network modulated by the prognostic signature transcription factors and their long noncoding RNA partners in primary prostate cancer. EBioMedicine. 2021 Jan;63:103150.

  8. Shi Q, Zhu Y, Ma J, Chang K, Ding D, Bai Y, Gao K, Zhang P, Mo R, Feng K, Zhao X, Zhang L, Sun H, Jiao D, Chen Y, Sun Y, Zhao SM, Huang H, Li Y, Ren S, Wang C，Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly. Mol Cancer. 2019 Nov 26;18(1):170.